Identification of prognostic and bone metastatic alternative splicing signatures in bladder cancer. Issue 1 (1st January 2021)

• Record Type: Journal Article
• Authors: Huang, Runzhi; Zheng, Zixuan; Xian, Shuyuan; Zhang, Jiayao; Jia, Jingyi; Song, Dianwen; Yan, Penghui; Yin, Huabin; Hu, Peng; Zhu, Xiaolong; Huang, Zongqiang; Meng, Tong; Zhang, Jie
• Is Part Of: Bioengineered. Volume 12:Issue 1(2021)
• Page Start: 5289
• Page End: 5304
• Publication Date: 2021-01-01
• Subjects: Alternative splicing -- bladder cancer -- prognosis -- bone metastasis -- signaling pathway; Biomedical engineering -- Periodicals; Biotechnology -- Periodicals; Microbiology -- Periodicals; 660.6
• DOI: 10.1080/21655979.2021.1964252
• Languages: English
• ISSNs: 2165-5987

Abstract

ABSTRACT: Bladder cancer (BLCA), originating from the epithelium of the urinary bladder, was the second most common malignancy in the urinary system with a high metastasis rate and poor post-metastasis prognosis. Alternative splicing events (ASEs) were regarded as important markers of tumor progression and prognosis, however, their roles in bladder cancer bone metastasis have not been recognized. In this study, we constructed a predictive model based on ASEs and explored the molecular mechanism of ASEs in BLCA bone metastasis, based on data from the Cancer Genome Atlas (TCGA) and TCGASpliceSeq databases. We proposed the hypothesis that the splicing events of ITGB4 was regulated by the splicing factor JUP, and this regulation might play a key role in BLCA bone metastasis through the glycosphingolipid biosynthesis ganglio series pathway.