(+)-7-O-Methylisomiroestrol, a new chromene phytoestrogen from the Pueraria candollei var. mirifica root. Issue 21 (2nd November 2021)

• Record Type: Journal Article
• Authors: Yusakul, Gorawit; Juengsanguanpornsuk, Wipawee; Sritularak, Boonchoo; Phaisan, Suppalak; Juengwatanatrakul, Thaweesak; Putalun, Waraporn
• Is Part Of: Natural product research. Volume 35:Issue 21(2021)
• Page Start: 4110
• Page End: 4114
• Publication Date: 2021-11-02
• Subjects: Pueraria mirifica -- methylisomiroestrol -- phytoestrogen -- oestrogenic assay; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1727473
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: (+)-7- O -Methylisomiroestrol (MeI), a novel chromene, was discovered as a phytoestrogen in the Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham (PM) root having been used as an active agent against oestrogen depletion disorders. The identification of PM phytochemicals is crucial for the development of standardised botanical drugs of PM. MeI was purified from the root cortex of PM, and its structure was elucidated using NMR and mass spectrometry. The content of MeI in the root bark of the PM root was 2.1–6.5 × 10 −3 % (w/w). The oestrogenic potency of MeI was stronger than that of isomiroestrol but less than that of deoxymiroestrol and miroestrol. Therefore, MeI is a new oestrogenic biomarker for the effective chemical standardisation of the PM extract for health product development. Graphical Abstract: