Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies. Issue 21 (2nd November 2021)

• Record Type: Journal Article
• Authors: Hamed, Abdelaaty; Abdel-Razek, Ahmed S.; Araby, Mariam; Abu-Elghait, Mohammed; El-Hosari, Doaa G.; Frese, Marcel; Soliman, Hesham S. M.; Stammler, Hans Georg; Sewald, Norbert; Shaaban, Mohamed
• Is Part Of: Natural product research. Volume 35:Issue 21(2021)
• Page Start: 3830
• Page End: 3838
• Publication Date: 2021-11-02
• Subjects: Meleagrin -- x-ray diffraction -- absolute configuration -- cytotoxicity -- antibiofilm-activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1741583
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The crystal structure and unambiguous absolute configuration of meleagrin (1 ) isolated from fungus Emericella dentata Nq45 is reported herein to first time on the bases of single crystal X-ray diffraction. Together with 1, haenamindole (2 ), isorugulosuvine (3 ), secalonic acid D (4 ), ergosterol (5 ) and cerebroside A (6 ) were obtained and their structures were determined by ESI MS and NMR data analysis. Diverse biological activity of meleagrin (1 ) was investigated. Compound 1 pronounced potent cytotoxicity against the human cervix carcinoma cell line KB-3-1 and its multidrug resistant sub-clone KB-V1 of IC50 3.07 and 6.07 µM, respectively, in comparison with the reference (+) – griseofulvin (IC50 19, 19.5 µM). Based on the antibiofilm activity, compound 1 displayed as well potent activity against Staphylococcus aureus with an MIC of 0.25 mg/mL. Isolation of the producing fungus and taxonomical characterization is stated as well. Graphical Abstract: