Polymorphism of genetic ambigrams. Issue 1 (19th April 2021)

• Record Type: Journal Article
• Authors: Dudas, Gytis; Huber, Greg; Wilkinson, Michael; Yllanes, David
• Is Part Of: Virus evolution. Volume 7:Issue 1(2021)
• Publication Date: 2021-04-19
• Subjects: metagenome -- narnavirus -- ambigram -- mosquito; Viruses -- Evolution -- Periodicals; 579.2138
• DOI: 10.1093/ve/veab038
• Languages: English
• ISSNs: 2057-1577

Abstract

Abstract: Double synonyms in the genetic code can be used as a tool to test competing hypotheses regarding ambigrammatic narnavirus genomes. Applying the analysis to recent observations of Culex narnavirus 1 and Zhejiang mosquito virus 3 ambigrammatic viruses indicates that the open reading frame on the complementary strand of the segment coding for RNA-dependent RNA polymerase does not code for a functional protein. Culex narnavirus 1 has been shown to possess a second segment, also ambigrammatic, termed 'Robin'. We find a comparable segment for Zhejiang mosquito virus 3, a moderately diverged relative of Culex narnavirus 1 . Our analysis of Robin polymorphisms suggests that its reverse open reading frame also does not code for a functional protein. We make a hypothesis about its role.