Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers. Issue 1 (1st January 2021)

• Record Type: Journal Article
• Authors: Martínez-Sanz, Javier; Jiménez, Daniel; Martínez-Campelo, Laura; Cruz, Raquel; Vizcarra, Pilar; Sánchez-Conde, Matilde; Ron, Raquel; Rodríguez, Mario; Herrera, Sabina; Moreno, Santiago; López-Huertas, María Rosa; Serrano-Villar, Sergio
• Is Part Of: Emerging microbes & infections. Volume 10:Issue 1(2021)
• Page Start: 493
• Page End: 496
• Publication Date: 2021-01-01
• Subjects: SARS-CoV-2 -- COVID-19 -- single-nucleotide polymorphism -- genetic variants -- susceptibility; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1080/22221751.2021.1902755
• Languages: English
• ISSNs: 2222-1751

Abstract

Abstract: We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23–11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09–10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.