Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study. Issue 1 (27th January 2023)

• Record Type: Journal Article
• Authors: Garcia-Rio, Francisco; Miravitlles, Marc; Soriano, Joan B; Cosío, Borja G; Soler-Cataluña, Juan José; Casanova, Ciro; de Lucas, Pilar; Alfageme, Inmaculada; Rodríguez González-Moro, José Miguel; Sánchez Herrero, María Guadalupe; Ancochea, Julio
• Other Names: author non-byline.; Castillo Elena García author non-byline.; Valenzuela Claudia author non-byline.; Bastida Ana Pueyo author non-byline.; Asegurado Lourdes Lázaro author non-byline.; Pascual Luis Rodríguez author non-byline.; Mora Mª José author non-byline.; Clau Luis Borderias author non-byline.; Mendoza Lourdes Arizón author non-byline.; García Sandra author non-byline.; Miranda Juan AR author non-byline.; Gutiérrez Julián Grande author non-byline.; Manzano Jesús Agustín author non-byline.; González Manuel author non-byline.; Ferrero Miguel Barrueco author non-byline.; Rosales Milagros author non-byline.; Villar José AF author non-byline.; Represas Cristina author non-byline.; Priegue Ana author non-byline.; Ferreño Isabel Portela author non-byline.; Roibás Cecilia Mouronte author non-byline.; García Sara Fernández author non-byline.; Cosío Borja G author non-byline.; Díaz Rocío Cordova author non-byline.; Pons Nuria Toledo author non-byline.; Llabrés Margalida author non-byline.; Trigo José MM author non-byline.; Forner Marta author non-byline.; Gallego Begoña author non-byline.; Cubero Pablo author non-byline.; Vera Elisabet author non-byline.; Albero Mª BP author non-byline.; García Noelia González author non-byline.; Morales Agustín Valido author non-byline.; Panadero Carolina author non-byline.; Bernáldez Cristina Benito author non-byline.; Velarde Maria author non-byline.; Siminiani Antonio Santa Cruz author non-byline.; Quintanilla Carlos Castillo author non-byline.; Meléndez Rocío Ibáñez author non-byline.; Garcerán José JM author non-byline.; Vicente Desirée Lozano author non-byline.; Torres Pedro García author non-byline.; Valdivia Maria del Mar author non-byline.; Tajes Juan PT author non-byline.; Girones Montserrat Cizur author non-byline.; Turrillas Carmen Labiano author non-byline.; Martínez Carlos Ruiz author non-byline.; Hernando Elena author non-byline.; Alfaro Elvira author non-byline.; García José Manuel author non-byline.; Lázaro Jorge author non-byline.; Bravo David author non-byline.; Hidalgo Laura author non-byline.; Terreros Silvia Francisco author non-byline.; Zorrilla Iñaki author non-byline.; Colmenero Ainara Alonso author non-byline.; González Cristina Martínez author non-byline.; Margon Susana author non-byline.; Taveras Rosirys Guzman author non-byline.; Fernández Ramón author non-byline.; Álvarez Alicia author non-byline.; Balbín José RA author non-byline.; Calvo Juan Agüero author non-byline.; Sancho Jaume Ferrer author non-byline.; González Esther Rodríguez author non-byline.; Loeb Eduardo author non-byline.; Alonso José LI author non-byline.; García Mª AR author non-byline.; González Juan Abreu author non-byline.; García Candelaria Martín author non-byline.; Muñoz Rebeca author non-byline.; García Haydée Martín author non-byline.; Muñiz Miguel AM author non-byline.; Antuña Andrés AS author non-byline.; González Jesús Allende author non-byline.; Blanco Jose AG author non-byline.; Navascues Fernando JA author non-byline.; Montes Manuel AV author non-byline.; Pericacho María Rodríguez author non-byline.; García Concepción Rodríguez author non-byline.; Mavárez Juan DA author non-byline.;
• Is Part Of: BMJ open respiratory research. Volume 10:Issue 1(2023)
• Publication Date: 2023-01-27
• Subjects: Tobacco and the lung -- Lung Physiology -- Imaging/CT MRI etc -- Exercise; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Diseases -- Treatment -- Periodicals; Respiratory therapy -- Periodicals; 616.2005
• DOI: 10.1136/bmjresp-2022-001468
• Languages: English
• ISSNs: 2052-4439

Abstract

Abstract : Background: Population distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications. Methods: A sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. Baseline evaluation included clinical questionnaires, exhaled carbon monoxide (CO) measurement, spirometry, DLCO determination, 6 min walk test, routine blood analysis and low-dose CT scan with evaluation of lung density and airway wall thickness. Results: In never, former and current smokers, prevalence of reduced DLCO was 6.7%, 14.4% and 26.7%, respectively. Current and former smokers with reduced DLCO without airflow limitation were younger than the subjects with normal DLCO, and they had greater levels of dyspnoea and exhaled CO, greater pulmonary artery diameter and lower spirometric parameters, 6 min walk distance, daily physical activity and plasma albumin levels (all p<0.05), with no significant differences in other chronic respiratory symptoms or CT findings. FVC and exhaled CO were identified as independent risk factors for low DLCO. Conclusion: Reduced DLCO is a frequent disorder among smokers without airflow limitation, associated with decreased exercise capacity and with CT findings suggesting that it may be a marker of smoking-induced early vascular damage. Trial registration number: NCT03028207 .