Accelerating periodontal regeneration through injectable hydrogel-enabled sequential delivery of nanoceria and erythropoietin. (January 2023)

• Record Type: Journal Article
• Authors: Li, Yuyang; Peng, Haoran; Tang, Wenyue; Gu, Deao; Ren, Shuangshuang; Yu, Yijun; Yang, Jie; Miao, Leiying
• Is Part Of: Materials & design. Volume 225(2023)
• Publication Date: 2023-01
• Subjects: Periodontitis -- Erythropoietin -- Nanoceria -- Hydrogel -- Regeneration; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2022.111540
• Languages: English
• ISSNs: 0264-1275

Abstract

Graphical abstract: Highlights: An injectable and plastic hydrogel was prepared as drug delivery for the irregular periodontal pocket after absorption. Ceria nanoparticle (CNP) and erythropoietin (EPO) were introduced into the hydrogel to realize anti-inflammation and osteogenic differentiation, respectively. The release of CNP was faster than EPO, which confirmed a favourable environment of anti-inflammation and provided a basis for osteogenesis. The results showed the strategy may be a promising candidate for periodontitis treatment. Abstract: Periodontitis is a chronic inflammatory disease characterized by persistent host immune overreaction, resulting in irregular alveolar shape after absorption, making local drug delivery a huge challenge. Herein, an injectable Fmoc-Phe3 hydrogel (FPH) with ceria nanoparticle (CNP) and erythropoietin (EPO) was prepared (EPO/CNP@FPH) for local drug delivery into the irregular periodontal pocket. The release of EPO and CNP was 61.33 % and 69.67 % respectively within the first 3 days and the release of CNP was faster than that of EPO during the process, which is the prerequisite for regeneration. The composite hydrogel enabled the switch in macrophage phenotype from M1 to M2 polarization by scavenging redundant ROS. It further increased the ability of angiogenesis and osteogensis. The EPO/CNP@FPH composite hydrogel exerted a remarkable therapeutic effects enabling irregular alveolar bone regeneration in rat model of periodontitis. Taken together, the hydrogel loaded with EPO and CNP showed a great potential for reducing inflammation and promoting periodontal regeneration in irregular regions, which may be a promising candidate for periodontitis treatment.