The effect of π-Conjugation on the self-assembly of micelles and controlled cargo release. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Liang, Yan; Sun, Yalin; Fu, Xiaoheng; Lin, Yang; Meng, Zhu; Meng, Yanan; Niu, Jiping; Lai, Yusi; Sun, Yong
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 48:Issue 1(2020)
• Page Start: 525
• Page End: 532
• Publication Date: 2020-01-01
• Subjects: Polymeric micelle -- π-π stacking interaction -- self-assembly -- Nile Red -- drug delivery; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2020.1725028
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Here we presented a novel micelle self-assembled from amphiphiles with π-conjugated moieties (OEG-DPH). The π-conjugated structural integrity of the micelles enabled stable encapsulation of Nile Red (NR, model drug). The self-assembly behaviour of the amphiphiles and the release profile of NR loaded micelles were investigated. Spherical core-shell structured NR loaded micelles with low CMC of 57 μg/mL and the efficient intracellular delivery process was monitored. This research provided a way to fabricate stable polymeric micelles and develop a practical nanocarrier for therapeutics delivery.