Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma for adults: A systematic review and meta-analysis (PRISMA-compliant article). Issue 50 (17th December 2021)

• Record Type: Journal Article
• Authors: Ko, Hung-Ju; Lin, Ying-Chun; Chen, Chieh-Chang; Chen, Ming-Jen; Wu, Ming-Shiang; Liu, Chun-Jen; Huang, Chun-Ta; Yang, Horng-Woei; Shih, Shou-Chuan; Yu, Lo-Yip; Kuo, Yang-Che; Wang, Horng-Yuan; Hu, Kuang-Chun
• Other Names: Saranathan. Maya section editor.
• Is Part Of: Medicine. Volume 100:Issue 50(2021)
• Publication Date: 2021-12-17
• Subjects: colorectal adenoma -- diabetes prevalence -- Helicobacter pylori; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000028156
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: Helicobacter pylori infection and hyperglycemia are associated with an increased risk of colorectal neoplasm, and may have a synergistic effect in combination. However, these 2 factors that affect colorectal neoplasm remain controversial. We aimed to carry out a meta-analysis to evaluate the study population diabetes prevalence rate and H pylori infection rate with colorectal adenoma risk for adults. Methods: We conducted systemic research through English databases for medical reports. We also recorded the diabetes prevalence and H pylori infection prevalence in each study. We classified these studies into 4 subgroups as their background population diabetes prevalence <6% (Group 1); between 6% and 8% (Group 2); between 8% and 10% (Group 3), and more than 10% (Group 4). The random-effects model had used to calculate pooled prevalence estimates with 95% confidence interval (CI). Results: Twenty-seven studies were finally eligible for meta-analysis. The random-effects model of the meta-analysis was chosen, showing pooled odds ratio (OR) equal to 1.51 (95% CI 1.39–1.63). The subgroup meta-analyses showed in Group 1 the H pylori infection associated colorectal adenoma risk OR was 1.24 (95% CI 0.86–1.78). As the diabetes rate exceed 6%, the H pylori infection became the more significant increased risk of colorectal adenoma (Group 2: OR 2.16 (95% CI 1.61–2.91); Group 3: OR 1.40 (95% CI 1.24–1.57); and Group 4: OR 1.52 (95% CI 1.46–1.57)). Conclusions: The results of this meta-analysis showed elevated diabetes prevalence combined H pylori infection increasing the risks of colorectal adenoma in the adult population.