Three new diterpenoids from Euphorbia peplus. Issue 21 (2nd November 2021)

• Record Type: Journal Article
• Authors: Chen, Yan-Ni; Lu, Qing-Yun; Li, Dong-Mei; Li, Ying-Yao; Pu, Xue-Xue; Li, Bo-Ting; Tang, Xiao-Han; Tang, Hong-Yu; Liu, Shuai; Yang, Lei; Zhang, Yu; Di, Ying-Tong; Fang, Xin; Hao, Xiao-Jiang
• Is Part Of: Natural product research. Volume 35:Issue 21(2021)
• Page Start: 3901
• Page End: 3907
• Publication Date: 2021-11-02
• Subjects: Euphorbiaceae -- Euphorbia peplus -- ent-abietane diterpenoids -- paralianone diterpenoids; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1749609
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new diterpenoids (1–3 ) (two abietane type diterpenoids and a paralianone type diterpenoid), together with four known compounds (4–7 ) were isolated from the whole plants of Euphorbia peplus . Their structures were elucidated through spectroscopic analysis and physicochemical characteristics. The cytotoxic activities of compounds 1–7 against five human tumour cell lines were evaluated, however, they were inactive at the concentration of 40 μM. The compound 3 enhanced lysosomal biogenesis with Lyso Tracker staining intensity of 132.6%. Graphical Abstract: