Relationship between consumption of MRSA-active antibiotics and burden of MRSA in acute care hospitals in Catalonia, Spain. (27th November 2014)

• Record Type: Journal Article
• Authors: Grau, Santiago; Fondevilla, Esther; Freixas, Núria; Mojal, Sergi; Sopena, Nieves; Bella, Feliu; Gudiol, Francesc; Balet, Antònia; Pérez, Rafel; Pons, Montserrat; García-Penche, Rosa; Pérez, Pepa; Barrera, Maria Teresa; Casas, Susana; Mestre, Gabriel; Berbel, Cristina; Enrique-Tarancon, Gemma; Caro, Silvia; Gayola, Glòria; Palau, Eva; Carrascossa, Montserrat; Valls, Camil·la; Martínez, Maria Jesús; Fuster, Mireia; Espejo, Elena; Ibañez, Ludivina; Sagalés, Maria; Vázquez, Rosa; Calonge, Mònica; Tricas, Josep Maria; Salse, Lídia; Gimeno, Elsa; Serrais, Juan; Brugués, Montse; López-Suñé, Ester; Marco, Francesc; Panisello, Manel; Terré, Susana; García, Ángeles; Arranz, Teresa; Cuscó, Maria; Grañó, Marisa; Pàez, Francesc; de la Fuente, José Carlos; Terré, Susana; Ferrer, Roser; Ayestaran, Ana; Sierra, Montserrat; Munell, Leonor; Grabulosa, Lourdes; Gol, Virginia; Gassiot, Paula; de Gamarra, Edurne Fernández; Lopez-Contreras, Joaquín; Smithson, Àlex; Campins, Lluís; Barrufet, Mª Pilar; Bosacoma, Núria; Oteiza, Amaia Concepción; Flotats, Elisenda; Morón, Anisi; Fernández, Inmaculada; Curiel, Olga; Agustí, Carme; Fraile, Maria José; Clarós, Mercè; Carrasco, Natàlia; Lérida, Ana; Espona, Mercè; Gómez, Julià; Vicente, Esther; Marcos, Pilar; Malo, Roger; Alonso-Tarrés, Carles; Capellà, Anna; Díaz, Vicens F.; Pascual, Begoña; Grau, Jordi; Garriga, Maria Rosa; Riera, Montserrat; Montserrat, Magda; Camps, Raimon; Benages, Núria; Blancas, David; Isern, Marta; Curriu, Margarida; Alemany, Pilar; Bisbe, Josep; Pujol, Francesca; Gasós, Mª Asunción; Juan, Núria San; Coloma, Ana Guadalupe; Martínez, Isabel; Capdevila, Pilar; Montardit, Irene; Canadell, Laura; García, Graciano; Cano, Santiago Manuel; Jover-Sáenz, Alfredo; Palomar, Mercedes; Padullés, Ariadna; Hornero, Ana; Motje, Montse; Campany, David; Larrosa, Nieves; Borràs, Ramon; Quesada, Maria Dolores; Matas, Lurdes; Salvador, Pilar; Castro, Antoni; Julián, M. Esther; Pérez, Mar Olga; Vidal, Maria Àngels; Villó, Josep Manel; Pujol, Miquel; Limon, Enric;
• Is Part Of: Journal of antimicrobial chemotherapy. Volume 70:Number 4(2015:Apr.)
• Page Start: 1193
• Page End: 1197
• Publication Date: 2014-11-27
• Subjects: defined daily dose -- MRSA -- vancomycin -- teicoplanin -- linezolid -- daptomycin; Anti-infective agents -- Periodicals; Chemotherapy -- Periodicals; 615.58
• DOI: 10.1093/jac/dku487
• Languages: English
• ISSNs: 0305-7453

Abstract

Abstract: Objectives: To analyse the possible relationship between consumption of old and new MRSA-active antibiotics and burden of MRSA in acute care hospitals in Catalonia during the period 2007–12. Methods: Fifty-four hospitals participating in the VINCat Programme were included. Proportion of MRSA (resistant isolates of Staphylococcus aureus per 100 isolates of S. aureus tested), incidence of new cases of infection [new cases of MRSA per 1000 occupied bed-days (OBD)] and incidence of cases of bacteraemia (MRSA bacteraemia cases per 1000 OBD) were determined to estimate the annual MRSA burden. Antibiotic consumption was calculated in DDD/100 OBD. Cost was expressed in euros/100 OBD. Results: MRSA rates remained stable over the study period, with the proportion of MRSA ranging from 20% to 22.82% in 2007 and 2012, respectively ( P = 0.864). Consumption of old MRSA-active antibiotics (vancomycin and teicoplanin) did not change significantly, with values from 1.51 to 2.07 DDD/100 OBD ( P = 0.693). Consumption of new MRSA-active antibiotics (linezolid and daptomycin) increased significantly, with values rising from 0.24 to 1.49 DDD/100 OBD ( P < 0.001). Cost increased by almost 200%. Conclusions: A widespread and steady increase in consumption of new MRSA-active antibiotics was observed among acute care hospitals in Catalonia, in spite of a stable MRSA burden. At the same time, consumption of old drugs remained stable. Such trends resulted in a significant increase in cost. Our findings suggest that factors other than the proportion of methicillin resistance among S. aureus may influence the use of old and new MRSA-active antibiotics in the clinical setting.