Association between dietary inflammatory index and upper aerodigestive tract cancer risk: A systematic review and dose-response meta-analysis. (April 2020)

• Record Type: Journal Article
• Authors: Zhu, Jiahao; Ling, Yuxiao; Mi, Shuai; Chen, Hanzhu; Fan, Jiayao; Cai, Shaofang; Fan, Chunhong; Shen, Qing; Li, Yingjun
• Is Part Of: Oral oncology. Volume 103(2020)
• Publication Date: 2020-04
• Subjects: Upper aerodigestive tract cancers -- Dietary inflammatory index -- Diet -- Inflammation -- Meta-analysis -- Dose-response; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2020.104587
• Languages: English
• ISSNs: 1368-8375

Abstract

Highlights: A one-unit increment in DII was associated with 18% increased UADT cancer risk. An upward trend was observed in association between DII and UADT cancer risk. Reducing pro-inflammatory components in diets should be considered to prevent UADT cancers. Abstract: Objectives: The relationship between dietary inflammatory index (DII) and upper aerodigestive tract (UADT) cancer risk have been investigated in a growing number of epidemiological studies. However, their findings were inconsistent, and no systematic review or meta-analysis has been conducted up to now. This meta-analysis was carried out to examine potential dose-response relationship between DII score and UADT cancer risk. Material and methods: A systematic search was conducted for relevant studies in PubMed and Web of Science up to March 28, 2019. Categorical meta-analysis as well as linear and non-linear dose-response meta-analysis were performed to evaluate association between DII and UADT cancer risk. Results: Nine case-control studies with a total of 4138 cases and 15, 326 healthy controls were eligible in the present meta-analysis. The pooled odds ratios (ORs) of UADT cancer risk were 2.07 [95% confidence interval (CI): 1.82, 2.35] for the highest DII score compared with the lowest and 1.53 (95% CI: 1.39, 1.69) for higher DII score compared with lower score, respectively. Furthermore, a one-unit increment in DII score was associated with an increased risk of 18% for UADT cancers (OR: 1.18; 95% CI: 1.15, 1.21). An upward trend towards a positive association between elevated DII score and UADT cancer risk was also observed in non-linear dose-response meta-analysis. Conclusions: The present meta-analysis provides evidence of highly pro-inflammatory diets that might increase risk of UADT cancers. Therefore, reducing pro-inflammatory components in diets should be considered to prevent and control UADT cancers.