Antibodies to Seasonal Coronaviruses Rarely Cross-React With SARS-CoV-2: Findings From an African Birth Cohort. Issue 12 (December 2021)

• Record Type: Journal Article
• Authors: Zar, Heather J.; Nicol, Mark P.; MacGinty, Rae; Workman, Lesley; Petersen, Wonita; Johnson, Marina; Goldblatt, David
• Is Part Of: Pediatric infectious disease journal. Volume 40:Issue 12(2021)
• Publication Date: 2021-12
• Subjects: seasonal coronavirus -- cross-protection -- antibodies -- child -- COVID-19; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000003325
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Antibodies to seasonal human-coronaviruses (sHCoV) may cross-protect against SARS-CoV-2. We investigated antibody responses in biobanked serum obtained before the pandemic from infants with polymerase chain reaction-confirmed sHCoV. Among 141 samples with antibodies to sHCoV, 4 (2.8%) were positive for SARS-CoV-2-S1 and 8 (5.7%) for SARS-CoV-2-S2. Antibodies to sHCoV rarely cross-react with SARS-CoV-2 antigens and are unlikely to account for mild pediatric illness. Abstract : Supplemental Digital Content is available in the text.