R-Hexitronic acid, a new tetronic acid derivative isolated from a soil fungus FG9RK. Issue 21 (2nd November 2021)

• Record Type: Journal Article
• Authors: Ngwoke, Kenneth G.; El-Kashef, Dina H.; Daletos, Georgios; Ancheeva, Elena; Liu, Zhen; Okoye, Festus B. C.; Esimone, Charles O.; Proksch, Peter
• Is Part Of: Natural product research. Volume 35:Issue 21(2021)
• Page Start: 3578
• Page End: 3583
• Publication Date: 2021-11-02
• Subjects: Tetronic acid -- furanone -- fungal metabolite -- soil fungi; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1715400
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new tetronic acid derivative (1 ) together with terrestric acid (2 ), a known metabolite of Penicillium species, was isolated from the soil fungus, FG9RK following fermentation on solid rice medium. The structure of 1 was elucidated by one- and two-dimensional NMR and MS measurements. The absolute configuration of the oxygenated carbon in the side chain of 1 was identified as S by converting the compound into its Mosher ester whereas the absolute configuration of the lactone ring was deduced based on biogenetic considerations and comparison with 2 . Graphical Abstract: