Essential oil of Cymbopogon citratus cultivated in Egypt: seasonal variation in chemical composition and anticholinesterase activity. Issue 21 (2nd November 2021)

• Record Type: Journal Article
• Authors: Madi, Yasmine F.; Choucry, Mouchira A.; Meselhy, Meselhy R.; El-Kashoury, El-Sayeda A.
• Is Part Of: Natural product research. Volume 35:Issue 21(2021)
• Page Start: 4063
• Page End: 4067
• Publication Date: 2021-11-02
• Subjects: Cymbopogon citratus -- acetylcholinesterase -- oil samples -- GC-MS -- citral; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1713125
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The yield of essential oil obtained by hydrodistillation of Cymbopogon citratus fresh leaves ranged from 0.15% to 0.46% w/w; being the highest in spring and the lowest in winter. The oil sample obtained in winter exhibited a moderate acetylcholinesterase inhibitory activity (IC50 2.86 ± 0.17 mg/mL), compared to physostigmine (IC50 0.012 mg/mL), while other samples were relatively weak (IC50 values of 2.86–5.40 mg/mL). In all samples, oxygenated monoterpenes were predominating (73.22–89.32%). GC-MS identified a total of 61, 25, 50 and 63 components in oil samples obtained in spring, summer, autumn and winter, respectively. Citral content was the highest in autumn and summer samples (82.02% and 80.01% citral; respectively) and the lowest in winter sample (60.01%). Citral, isolated from the oil demonstrated a relatively potent anticholinesterase activity (IC50 0.21 ± 0.01 mg/mL). Graphical Abstract: