Applanaic acids A–C, three new highly oxygenated lanostane triterpenoids from the fruiting bodies of Ganoderma applanatum. Issue 21 (2nd November 2021)

• Record Type: Journal Article
• Authors: Chen, Yu; Gao, Jie; Chen, Qibin; Liu, Wei; Qi, Yanru; Aisa, Haji Akber; Yuan, Tao
• Is Part Of: Natural product research. Volume 35:Issue 21(2021)
• Page Start: 3918
• Page End: 3924
• Publication Date: 2021-11-02
• Subjects: Ganoderma applanatum -- lanostane triterpenoid -- applanaic acid -- AChE; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1749612
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new highly oxygenated lanostane triterpenoids, applanaic acids A–C (1 –3 ), were isolated from the fruiting bodies of the basidiomycete Ganoderma applanatum. Among them, applanaic acid B (2 ) possessed the Δ 17(20) -double bond connection between the side chain and the tetracyclic skeleton, which was not common in the natural lanostane triterpenoids. Their structures were determined by 1D, 2D NMR and HRESIMS spectroscopic analysis. Compound 3 showed a weak acetylcholinesterase (AchE) inhibitory activity with 33.5% inhibition rate at 50 μM.