Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019. (17th April 2021)

• Record Type: Journal Article
• Authors: Regan, James; Flynn, James P; Rosenthal, Alexandra; Jordan, Hannah; Li, Yijia; Chishti, Rida; Giguel, Francoise; Corry, Heather; Coxen, Kendyll; Fajnzylber, Jesse; Gillespie, Elizabeth; Kuritzkes, Daniel R; Hacohen, Nir; Goldberg, Marcia B; Filbin, Michael R; Yu, Xu G; Baden, Lindsey; Ribeiro, Ruy M; Perelson, Alan S; Conway, Jessica M; Li, Jonathan Z
• Is Part Of: Open forum infectious diseases. Volume 8:Number 8(2021)
• Publication Date: 2021-04-17
• Subjects: COVID-19 -- remdesivir -- SARS-CoV-2 -- viral kinetics -- viral load; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab153
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.