Sulphated flavones and pregnane-type steroids from Helicteres viscida. Issue 20 (23rd September 2021)

• Record Type: Journal Article
• Authors: Truong, Luu Hong; Cuong, Nguyen Hieu; Dang, Tran Huu; Dung, Trinh Thi My; Cham, Pham Thi; Hanh, Tran Thi Hong; Quang, Tran Hong; Dang, Nguyen Hai; Cuong, Nguyen Xuan; Nam, Nguyen Hoai; Minh, Chau Van
• Is Part Of: Natural product research. Volume 35:Issue 20(2021)
• Page Start: 3390
• Page End: 3395
• Publication Date: 2021-09-23
• Subjects: Helicteres viscida -- Malvaceae -- sulphated flavone -- pregnane-type steroid; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1700253
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In our search for anti-inflammatory constituents from Vietnamese plants, the methanolic extract of Helicteres viscida was found to exhibit inhibitory effect on LPS-induced NO production in RAW264.7 cells. Phytochemical investigation of this plant led to isolation of four sulphated flavones (1–4 ), including one new compound 5, 3′, 4′-trihydroxy-7-methoxy-8- O -sulphate flavone (1 ), and two pregnane-type steroids (5 and 6 ), including one new compound 7- epi -heligenin B (5 ). Their structures were elucidated by 1D and 2D NMR as well as HR-QTOF-MS experiments. Among isolated compounds, heligenin B (6 ) exhibited potent inhibitory effect on LPS-induced NO production in RAW264.7 cells with IC50 of 1.23 ± 0.05 µM. The activity of 6 was comparable to that of the positive control cardamonin. Graphical Abstract: