Granulocyte Macrophage Colony-Stimulating Factor-Specific Autoantibodies and Cerebral Nocardia With Pulmonary Alveolar Proteinosis. (13th December 2020)

• Record Type: Journal Article
• Authors: Berthoux, Charlotte; Mailhe, Morgane; Vély, Frédéric; Gauthier, Clarisse; Mège, Jean-Louis; Lagier, Jean-Christophe; Melenotte, Cléa
• Is Part Of: Open forum infectious diseases. Volume 8:Number 2(2021)
• Publication Date: 2020-12-13
• Subjects: Nocardia -- Pulmonary alveolar proteinosis' Anti-GM-CSF antibody; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa612
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: In this study, we report the history of a 40-year-old man with a primary cerebral abscess caused by Nocardia abscessus that led to the discovery of autoimmune pulmonary alveolar lipoproteinosis (anti-granulocyte-macrophage colony-stimulating factor [GM-CSF] autoantibodies). Anti-GM-CSF autoantibodies promote immunodeficiency and should be monitored to prevent opportunistic and disseminated infections and to diagnose asymptomatic pulmonary alveolar lipoproteinosis.