Aflatoxins from the endophytic fungus Aspergillus sp. Y-2 isolated from the critically endangered conifer Abies beshanzuensis. Issue 19 (2nd October 2021)

• Record Type: Journal Article
• Authors: Zhu, Yuan-Xing; Peng, Cheng; Yu, Shui; Hu, Jin-Feng; Li, Jiyang
• Is Part Of: Natural product research. Volume 35:Issue 19(2021)
• Page Start: 3248
• Page End: 3253
• Publication Date: 2021-10-02
• Subjects: Abies beshanzuensis -- endophytic fungus -- Aspergillus sp. -- aflatoxins -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1696328
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new [asperxins A (1 ) and B (2 )] and four known (3 –6 ) aflatoxins were isolated and identified from the endophytic fungus Aspergillus sp. Y-2, which was derived from the needles of the critically endangered conifer Abies beshanzuensis . Their structures were elucidated by extensive spectroscopic methods. Among the isolates, compounds 1 and 5 showed considerable cytotoxicities against the A549 and Hela human cancer cell lines, with IC50 values in the range of 7.5–16.8 μM. Graphical Abstract: UF0001