Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection. Issue 1 (1st January 2021)

• Record Type: Journal Article
• Authors: Sun, Encheng; Huang, Lianyu; Zhang, Xianfeng; Zhang, Jiwen; Shen, Dongdong; Zhang, Zhenjiang; Wang, Zilong; Huo, Hong; Wang, Wenqing; Huangfu, Haoyue; Wang, Wan; Li, Fang; Liu, Renqiang; Sun, Jianhong; Tian, Zhijun; Xia, Wei; Guan, Yuntao; He, Xijun; Zhu, Yuanmao; Zhao, Dongming; Bu, Zhigao
• Is Part Of: Emerging microbes & infections. Volume 10:Issue 1(2021)
• Page Start: 2183
• Page End: 2193
• Publication Date: 2021-01-01
• Subjects: African swine fever virus -- genotype I -- virulence -- pig -- China; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1080/22221751.2021.1999779
• Languages: English
• ISSNs: 2222-1751

Abstract

ABSTRACT: The Georgia-07-like genotype II African swine fever virus (ASFV) with high virulence has been prevalent in China since 2018. Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Henan and Shandong province, respectively. Phylogenetic analysis of the whole genome sequences suggested that both isolates share high similarity with NH/P68 and OURT88/3, two genotype I ASFVs isolated in Portugal in the last century. Animal challenge testing revealed that SD/DY-I/21 shows low virulence and efficient transmissibility in pigs, and causes mild onset of infection and chronic disease. SD/DY-I/21 was found to cause necrotic skin lesions and joint swelling. The emergence of genotype I ASFVs will present more problems and challenges for the control and prevention of African swine fever in China.