The HLA-B*13:01 and the dapsone hypersensitivity syndrome in Korean and Asian populations: genotype- and meta-analyses. Issue 10 (2nd October 2020)

• Record Type: Journal Article
• Authors: Park, Hye Jung; Park, Jung-Won; Kim, Sae Hoon; Choi, So-Yun; Kim, Hee-Kyoo; Jung, Chang-Gyu; Yang, Min-Suk; Kang, Dong Yoon; Cho, Min-Kyoung; Kwon, Hyouk-Soo; Kang, Hye-Ryun; Lee, Yong Won
• Is Part Of: Expert opinion on drug safety. Volume 19:Issue 10(2020)
• Page Start: 1349
• Page End: 1356
• Publication Date: 2020-10-02
• Subjects: Dapsone -- human leukocyte antigen -- HLA-B*13:01 -- hypersensitivity syndrome; Drugs -- Side effects -- Periodicals; Drugs -- Toxicology -- Periodicals; Chemotherapy -- Periodicals; 615.704
• DOI: 10.1080/14740338.2020.1796965
• Languages: English
• ISSNs: 1474-0338

Abstract

ABSTRACT: Background: The human leukocyte antigen (HLA)-B*13:01 was reported as an important risk factor for dapsone hypersensitivity syndrome (DHS) in Chinese and Thai populations. Research design and methods: From the Korean nationwide registry, seven subjects with previous DHS were included. Their HLA allele/phenotype frequencies were compared with 8 dapsone-tolerant subjects recruited from a single institution, and general population (n = 485) in Korea. The authors also performed a meta-analysis with these data using previous Chinese and Thai studies. Results: Among the seven DHS subjects, 85.7% presented with the HLA-B*13:01 allele. The HLA-C*03:04, HLA-DRB1*12:02 (both in linkage disequilibrium with HLA-B*13:01), and HLA-A*02:01 alleles were also presented in 85.7%, 71.4%, and 71.4%, respectively. Subjects with HLA-B*13:01 were susceptible to developing DHS compared to dapsone-tolerant controls (odds ratio [OR]: 73.667) and the Korean general population (OR: 139.500). HLA-C*03:04 (OR: 40.935), HLA-DRB*12:02 (OR: 36.613), and HLA-A*02:01 (OR: 5.862) showed similar results. In meta-analysis, HLA-B*13:01 was associated with dapsone-induced hypersensitivity (overall OR: 42.692), and subgroup analyses according to the control types demonstrated similar results (OR:43.694 and 41.866, respectively). Conclusions: Similar to previous Asian population studies, HLA-B*13:01 is significantly associated with the risk of DHS in Korea. These associations may be useful for preventing DHS and improving drug safety.