Usual Interstitial Pneumonia Associated With Crystalline Silica Exposure in Pneumoconiosis: A Retrospective Cohort Study. Issue 12 (December 2021)

• Record Type: Journal Article
• Authors: Kang, WonYang; Kim, Daeho; Kim, Mi-Yeon; Kim, Boowook; Shin, Jungah; Kim, Eun Young; Choi, Sungwon; Cha, Wonseok; Choi, Byung-Soon
• Is Part Of: Journal of occupational and environmental medicine. Volume 63:Issue 12(2021)
• Publication Date: 2021-12
• Subjects: crystalline silica -- idiopathic interstitial pneumonia -- idiopathic pulmonary fibrosis -- occupational exposure -- pneumoconiosis -- usual interstitial pneumonia; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational Medicine -- Periodicals; Environmental Medicine -- Periodicals; Environmental health; Medicine, Industrial; Periodicals; Electronic journals; 616.9803
• DOI: 10.1097/JOM.0000000000002399
• Languages: English
• ISSNs: 1076-2752

Abstract

Abstract : Objective: We aimed to identify a relation between the level of silica exposure and the associated increase in the risk of radiologic usual interstitial pneumonia (UIP) pattern. Methods: We selected data of 796 individuals with pneumoconiosis who had undergone a chest computed tomography (CT). We estimated the silica exposure by comparing their occupational history with the data silica dust exposure. Results: Individuals employed as stonemasons demonstrated a 2.30-fold increase in the risk of developing UIP than coal mine workers (odds ratio [OR], 2.30; 95% confidence interval [CI], 1.04 to 5.07). The high silica exposure group was associated with a 2.23-fold increase in the risk of developing UIP than the low silica exposure group (OR, 2.23; 95% CI, 1.07 to 4.69). Conclusions: This study suggests that silica exposure is associated with an increased risk of developing UIP pattern, highlighting a dose–response relationship.