Donor-Derived CD4+ T Cells and Human Herpesvirus 6B Detection After Allogeneic Hematopoietic Cell Transplantation. (14th July 2020)

• Record Type: Journal Article
• Authors: Hanson, Derek J; Xie, Hu; Zerr, Danielle M; Leisenring, Wendy M; Jerome, Keith R; Huang, Meei-Li; Stevens-Ayers, Terry; Boeckh, Michael; Koelle, David M; Hill, Joshua A
• Is Part Of: Journal of infectious diseases. Volume 223:Number 4(2021)
• Page Start: 709
• Page End: 713
• Publication Date: 2020-07-14
• Subjects: human herpesvirus 6 -- HHV-6 -- CD4+ T cell -- hematopoietic cell transplant; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa422
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: We sought to determine whether donor-derived human herpesvirus (HHV) 6B–specific CD4 + T-cell abundance is correlated with HHV-6B detection after allogeneic hematopoietic cell transplantation. We identified 33 patients who received HLA-matched, non–T-cell–depleted, myeloablative allogeneic hematopoietic cell transplantation and underwent weekly plasma polymerase chain reaction testing for HHV-6B for 100 days thereafter. We tested donor peripheral blood mononuclear cells for HHV-6B–specific CD4 + T cells. Patients with HHV-6B detection above the median peak viral load (200 copies/mL) received approximately 10-fold fewer donor-derived total or HHV-6B–specific CD4 + T cells than those with peak HHV-6B detection at ≤200 copies/mL or with no HHV-6B detection. These data suggest the importance of donor-derived immunity for controlling HHV-6B reactivation. Abstract : We demonstrated that a higher number of donor-derived total and human herpesvirus (HHV) 6B–specific CD4 + T cells may reduce the risk for higher-level HHV-6B detection after allogeneic hematopoietic cell transplantation.