Neuron-Type-Specific Utility in a Brain-Machine Interface: a Pilot Study. (2nd November 2017)

• Record Type: Journal Article
• Authors: Garcia-Garcia, Martha G.; Bergquist, Austin J.; Vargas-Perez, Hector; Nagai, Mary K.; Zariffa, Jose; Marquez-Chin, Cesar; Popovic, Milos R.
• Is Part Of: Journal of spinal cord medicine. Volume 40:Number 6(2017:Nov.)
• Page Start: 715
• Page End: 722
• Publication Date: 2017-11-02
• Subjects: Brain-computer interface -- Brain-machine interface -- Firing rate -- Modulation -- Motor cortex -- Neuron -- Operant conditioning -- Spike width -- Upregulation -- Waveform width; Spinal cord -- Wounds and injuries -- Periodicals; Spinal cord -- Diseases -- Periodicals; 616.8305
• DOI: 10.1080/10790268.2017.1369214
• Languages: English
• ISSNs: 1079-0268

Abstract

Abstract : Context: Firing rates of single cortical neurons can be volitionally modulated through biofeedback (i.e. operant conditioning), and this information can be transformed to control external devices (i.e. brain-machine interfaces; BMIs). However, not all neurons respond to operant conditioning in BMI implementation. Establishing criteria that predict neuron utility will assist translation of BMI research to clinical applications. Findings: Single cortical neurons (n=7) were recorded extracellularly from primary motor cortex of a Long-Evans rat. Recordings were incorporated into a BMI involving up-regulation of firing rate to control the brightness of a light-emitting-diode and subsequent reward. Neurons were classified as 'fast-spiking', 'bursting' or 'regular-spiking' according to waveform-width and intrinsic firing patterns. Fast-spiking and bursting neurons were found to up-regulate firing rate by a factor of 2.43±1.16, demonstrating high utility, while regular-spiking neurons decreased firing rates on average by a factor of 0.73±0.23, demonstrating low utility. Conclusion/Clinical Relevance: The ability to select neurons with high utility will be important to minimize training times and maximize information yield in future clinical BMI applications. The highly contrasting utility observed between fast-spiking and bursting neurons versus regular-spiking neurons allows for the hypothesis to be advanced that intrinsic electrophysiological properties may be useful criteria that predict neuron utility in BMI implementation.