Secondary metabolites of Curvularia sp. G6-32, an endophyte of Sapindus saponaria, with antioxidant and anticholinesterasic properties. Issue 21 (2nd November 2021)

• Record Type: Journal Article
• Authors: Polli, Andressa Domingos; Ribeiro, Marcos Alessandro dos Santos; Garcia, Adriana; Polonio, Julio Cesar; Santos, Caroline Menicoze; Silva, Angela Aparecida; Orlandelli, Ravely Casarotti; Castro, Juliana Cristina; Abreu-Filho, Benício Alves; Cabral, Marcia Regina Pereira; Sarragiotto, Maria Helena; Pamphile, João Alencar; Azevedo, João Lúcio
• Is Part Of: Natural product research. Volume 35:Issue 21(2021)
• Page Start: 4148
• Page End: 4153
• Publication Date: 2021-11-02
• Subjects: (-)-Asperpentyn -- bioactive natural compounds -- ESI-MS -- spectroscopic analysis -- structure elucidation; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1739681
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In the present study, the biological activity of an extract of the secondary metabolites (E-G6-32) produced by the Curvularia sp. G6-32 endophyte (isolated from the medicinal plant Sapindus saponaria L.) was investigated. The antioxidant potential was confirmed by the DPPH (22.5%) and ABTS (62.7%) assays, and the total phenolic compound content was 40 µg gallic acid equivalents/mg. The extract E-G6-32 displayed good inhibitory activity toward butyrylcholinesterase (BuChE; IC50 = 110 ± 0.05 µg mL −1 ). The extract E-G6-32 was subjected to spectroscopic and mass spectrometry analyses. Comparison with the literature data confirmed that (-)-asperpentyn (1 ) was a major component. Asperpentyn belongs to the epoxyquinone family, which has attractive structural complexity, diverse functional groups, and a broad range of biological activities, including specific enzyme inhibitory activity. Our results suggest that Curvularia sp. G6-32 is a promising source of bioactive secondary metabolites and contains (-)-asperpentyn, which has potential pharmaceutical interest.