Senegalin, a new phenylpropanoid and other secondary metabolites from the stem bark of Ekebergia senegalensis A. Juss. (Meliaceae). Issue 21 (2nd November 2021)

• Record Type: Journal Article
• Authors: Kemayou, Guy Paulin M.; Happi, Gervais M.; Ngandjui, Yvan Anderson T.; Tchouankeu, Jean Claude; Sewald, Norbert; Ali, Muhammad S.; Kouam, Simeon F.
• Is Part Of: Natural product research. Volume 35:Issue 21(2021)
• Page Start: 3694
• Page End: 3700
• Publication Date: 2021-11-02
• Subjects: Senegalin -- Ekebergia senegalensis -- Meliaceae -- phenylpropanoid -- antibacterial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1729151
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Senegalin (1 ), a new phenylpropanoid has been isolated from the stem bark of Ekebergia senegalensis A. Juss. along with twelve known secondary metabolites including coumarins 2 –5, 4-hydroxy-3, 5-methylbenzoic acid (6 ), pentacyclic triterpenoids 7 –9, acyclic triterpenoids 10 and 11 and steroids 12 and 13, respectively. Their structures were elucidated with the help of spectroscopic techniques including 1 D- and 2 D-NMR. The antibacterial activity of the major compounds (2, 9 –11 ) was evaluated on five bacterial strains. However, only compounds 2 and 11 showed a weak inhibition against Bacillus subtilis and Pseudomonas agarici . Furthermore, the chemotaxonomic significance of these compounds has also been elaborated. GRAPHICAL ABSTRACT: