Two new sterol derivatives isolated from the endophytic fungus Aspergillus tubingensis YP-2. Issue 19 (2nd October 2021)

• Record Type: Journal Article
• Authors: Yu, Shui; Zhu, Yuan-Xing; Peng, Cheng; Li, Jiyang
• Is Part Of: Natural product research. Volume 35:Issue 19(2021)
• Page Start: 3277
• Page End: 3284
• Publication Date: 2021-10-02
• Subjects: Aspergillus tubingensis -- endophytic fungus -- secondary metabolites -- ergosterimide B -- demethylincisterol A5 -- cytotoxicities; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1696793
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new sterol derivatives, namely ergosterimide B (1 ) and demethylincisterol A5 (2 ), along with eleven known metabolites (3–13 ), were isolated from the rice fermentation culture of Aspergillus tubingensis YP-2. The chemical structures were elucidated by detailed NMR and MS spectroscopic data and by comparison with reported data. Newly isolated compound 2 and known compound 3 were evaluated for their cytotoxicities against the A549 and HepG2 cell lines. Compound 2 showed weak activities with IC50 values of 11.05 and 19.15 μM, respectively, while 3 exhibited cytotoxicities with IC50 values of 5.34 and 12.03 μM, respectively, against the tested cell lines. Graphical Abstract: UF0001