Cross-neutralization of Omicron subvariants after heterologous NVX-CoV2373 boosters: Comparison between prior SARS-CoV-2-infected and infection-naive individuals. Issue 2 (February 2023)

• Record Type: Journal Article
• Authors: Choi, Min Joo; Choi, Ju-Yeon; Hyun, Hakjun; Nham, Eliel; Seong, Hye; Yoon, Jin Gu; Noh, Ji Yun; Cheong, Hee Jin; Kim, Woo Joo; Kim, Su-Hwan; Jeong, Hyeonji; Kim, Min-Seong; Kim, Byoungguk; Song, Joon Young
• Is Part Of: Journal of infection. Volume 86:Issue 2(2023)
• Page Start: e46
• Page End: e48
• Publication Date: 2023-02
• Subjects: Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2022.09.018
• Languages: English
• ISSNs: 0163-4453

Abstract

Highlights: We investigated the cross-reactive immunity against omicron BA.1/BA.5 in the individuals with heterologous NVX-CoV2373 booster. Both third- and fourth-dose heterologous NVX-CoV2373 boosters enhanced cross-reactive immunity against omicron BA.1/BA.5 subvariants. Remarkable ceiling effects were observed in the individuals with prior SARS-CoV-2 infection. Prior SARS-CoV-2 infection may provide better cross-protection against diverse omicron subvariants.