First pregnancy in China after ovarian tissue transplantation to prevent premature ovarian insufficiency. (2nd November 2021)

• Record Type: Journal Article
• Authors: Ruan, X.; Du, J.; Lu, D.; Duan, W.; Jin, F.; Kong, W.; Wu, Y.; Dai, Y.; Yan, S.; Yin, C.; Li, Y.; Cheng, J.; Jia, C.; Liu, X.; Wu, Q.; Gu, M.; Ju, R.; Xu, X.; Yang, Y.; Jin, J.; Korell, M.; Montag, M.; Liebenthron, J.; Mueck, A. O.
• Is Part Of: Climacteric. Volume 24:Number 6(2021)
• Page Start: 624
• Page End: 628
• Publication Date: 2021-11-02
• Subjects: Ovarian tissue cryopreservation -- transplantation -- pregnancy -- premature ovarian insufficiency; Menopause -- Periodicals; Menopause -- Hormone therapy -- Periodicals; Menopause -- Periodicals; Estrogen Replacement Therapy -- Periodicals; Gynecology -- Periodicals; Societies, Medical -- Periodicals; 612.665
• DOI: 10.1080/13697137.2021.1956453
• Languages: English
• ISSNs: 1369-7137

Abstract

Abstract: Objective: This article reports the first case of pregnancy after frozen–thawed ovarian tissue transplantation to prevent iatrogenic premature ovarian insufficiency in China. Methods: Ovarian tissue cryopreservation was performed in a patient with myelodysplastic syndrome (MDS) before multi-agent chemotherapy and hematopoietic stem cell transplantation. Two years later, she showed complete remission from MDS, and six frozen–thawed ovarian tissue strips were transplanted into the peritoneal pocket. Results: The patient's ovarian activity was restored 3 months after transplantation, and pregnancy occurred spontaneously 27 months after grafting. Until now, the pregnancy has progressed for 30 weeks, and the repeated ultrasound showed normal fetal development. Conclusion: This is the first pregnancy resulting from ovarian tissue cryopreservation and transplantation in China.