Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission. (21st April 2015)

• Record Type: Journal Article
• Authors: Chéret, Antoine; Bacchus-Souffan, Charline; Avettand-Fenoël, Veronique; Mélard, Adeline; Nembot, Georges; Blanc, Catherine; Samri, Assia; Sáez-Cirión, Asier; Hocqueloux, Laurent; Lascoux-Combe, Caroline; Allavena, Clotilde; Goujard, Cécile; Valantin, Marc Antoine; Leplatois, Anne; Meyer, Laurence; Rouzioux, Christine; Autran, Brigitte; Hoen, B.; Bourdeaux, C.; Delfraissy, J. F.; Goujard, C.; Amri, I.; Fourn, E.; Quertainmont, Y.; Môle, M.; Rami, A.; Durel, A.; Diemer, M.; Parrinello, M.; Allègre, T.; Lafeuillade, A.; Hittinger, G.; Lambry, V.; Carrerre, M.; Philip, G.; Duvivier, C.; Consigny, P. H.; Charlier, C.; Shoai, M.; Touam, F.; Pialoux, G.; Slama, L.; L'Yavanc, T.; Mathurin, P.; Adda, A.; Berrebi, V.; Salmon, D.; Chakvetadze, E.; Tassadit, T.; Ousseima, E.; Pietri, M. P.; Levy, Y.; Lascaux, A. S.; Lelievre, J. D.; Giovanna, M.; Dominguez, S.; Dumont, C.; Katlama, C.; Valentin, M. A.; Seang, S.; Schneider, L.; Kiorza, N.; Chermak, A.; Ben Abdallah, S.; Simon, A.; Pichon, F.; Pauchard, M.; Molina, J. M.; Lascoux, C.; Ponscarme, D.; Colin De Verdiere, N.; Scemla, A.; De Castro, N.; Rachline, A.; Garrait, V.; Rozenbaum, W.; Ferret, S.; Balkan, S.; Clavel, F.; Tourdjman, M.; Lafaurie, M.; Aslan, A.; Goguel, J.; Thierry, S. M.; De Lastours, V.; Gallien, S.; Pavie, J.; Delgado, J.; Mededji, C.; Veron, R.; Abel, S.; Pierre-François, S.; Baringhton, C.; Chennebault, J. M.; Vandamme, Y. M.; Fialaire, P.; Rehaiem, S.; Rabier, V.; Abgueguen, P.; Morlat, P.; Vandenhende, M. A.; Bernard, N.; Lacoste, D.; Michaux, C.; Paccalin, F.; Receveur, M. C.; Caldato, S.; Delaune, J.; Ragnaud, J. M.; Neau, D.; Lacaze-Buzy, L.; Livrozet, J. M.; Jeanblanc, F.; Makhloufi, D.; Brunel Dalmas, F.; Jourdain, J. J.; Chiarello, P.; Yeni, P.; Phung, B.; Rioux, C.; Godard, C.; Louni, F.; El Alami Talbi, N.; Catalano, G.; Guiroy, F.; Reynes, J.; Jacquet, J. M.; Fauchere, V.; Merle, C.; Lemoine, V.; Loriette, M.; Morquin, D.; Makinson, A.; Atoui, N.; Tramoni, C.; Raffi, F.; Allavena, C.; Bonnet, B.; Bouchez, S.; Feuillebois, N.; Brunet-François, C.; Reliquet, V.; Mounoury, O.; Morineau-Le-Houssine, P.; Billaud, E.; Brosseau, D.; Hüe, H.; Dellamonica, P.; Vassallo, M.; Leplatois, A.; Durant, J.; Naqvi, A.; Joulié, A.; Souala, F.; Michelet, C.; Arvieux, C.; Tattevin, P.; Leroy, H.; Revest, M.; Fily, F.; Chapplain, J. M.; Ratajczak, C. M.; Gras, G.; Bernard, L.; Dailloux, J. F.; Laplantine, V.; Cuzin, L.; Marchou, B.; Larrigue, S.; Chauveau, M.; Balsarin, F.; Obadia, M.; Chéret, A.; Bonne, S.; Huleux, T.; Ajana, F.; Alcaraz, I.; Baclet, V.; Melliez, H.; Viget, N.; De La Tribonniere, X.; Aissi, E.; Poissy, J.; Ravaux, I.; Vallon, A.; Varan, M.; May, T.; Letranchant, L.; Burty, C.; Briaud, A.; Wassoumbou, S.; Stenzel, M.; Bouillon, M. P.; Debab, Y.; Caron, F.; Gueit, I.; Chapuzet, C.; Borsa Lebas, F.; Etienne, M.; Miailhes, P.; Perpoint, T.; Senechal, A.; Schlienger, I.; Cotte, L.; Augustin Normand, C.; Boibieux, A.; Ferry, T.; Corsini, N.; Braun, E.; Lippran, J.; Biron, F.; Chidiac, C.; Pailhes, S.; Lipman, J.; Braun, E.; Koffi, J.; Thoirain, V.; Brochier, C.; Greder Belan, A.; Therby, A.; Monnier, S.; Ruquet, M.; Garrait, V.; Richier, L.; Prevoteau Du Clary, F.; Philibert, P.; Chapus, C.; Cabié, A.; Abel, S.;
• Is Part Of: Journal of antimicrobial chemotherapy. Volume 70:Number 7(2015:Jul.)
• Page Start: 2108
• Page End: 2120
• Publication Date: 2015-04-21
• Subjects: primary HIV infections -- post-treatment controllers -- HIV DNA -- reservoirs; Anti-infective agents -- Periodicals; Chemotherapy -- Periodicals; 615.58
• DOI: 10.1093/jac/dkv084
• Languages: English
• ISSNs: 0305-7453

Abstract

Abstract: Background: Therapeutic control of HIV replication reduces the size of the viral reservoir, particularly among central memory CD4+ T cells, and this effect might be accentuated by early treatment. Methods: We examined the effect of ART initiated at the time of the primary HIV infection (early ART), lasting 2 and 6 years in 11 and 10 patients, respectively, on the HIV reservoir in peripheral resting CD4+ T cells, sorted into naive (TN), central memory (TCM), transitional memory (TTM) and effector memory (TEM) cells, by comparison with 11 post-treatment controllers (PTCs). Results: Between baseline and 2 years, CD4+ T cell subset numbers increased markedly ( P < 0.004) and HIV DNA levels decreased in all subsets ( P < 0.009). TTM cells represented the majority of reservoir cells at both timepoints, T cell activation status normalized and viral diversity remained stable over time. The HIV reservoir was smaller after 6 years of early ART than after 2 years ( P < 0.019), and did not differ between PTCs and patients treated for 6 years. One patient, who had low reservoir levels in all T cell subsets after 2 years of treatment similar to the levels in PTCs, spontaneously controlled viral replication during 18 months off treatment. Conclusions: Early prolonged ART thus limits the size of the HIV reservoir, protects long-lived cells from persistent infection and may enhance post-treatment control.