Direct Detection of NT- Pro BNP As a Cardiac Biomarker Using High Electron Mobility Transistors in Physiological Salt Environment. (28th April 2016)

• Record Type: Journal Article
• Authors: Regmi, Abiral; Sarangadharan, Indu; Chen, Yan Wen; Hsu, Chen-Pin; Wang, Yu-Lin
• Is Part Of: ECS transactions. Volume 72:Number 6(2016)
• Page Start: 19
• Page End: 23
• Publication Date: 2016-04-28
• Subjects: Electrochemistry -- Periodicals; Electrochemistry; Periodicals; Electronic journals; Electronic journal; 541.37
• DOI: 10.1149/07206.0019ecst
• Languages: English
• ISSNs: 1938-5862

Abstract

Abstract : Cardiovascular disease (CVD) is one of the major causes to claim millions of lives all across the globe every year. While the chances of CVD increase with age, it can also occur in any age group of people, both male and female. Despite all efforts and tremendous accomplishments in the precaution and treatment of CVD, its detection at an early stage is still a big challenge for scientists in this present modern world. Here, NT-pro BNP plays a crucial role in acute congestive heart failure since it is biologically inactive, binds better with its receptors and has a longer half-life than any other, making it an ideal biomarker. The detection method is based upon the ligand-receptor interaction, also called as immunoassay, which can be successfully detected with the use of High Electron Mobility Transistors (HEMTs) with short duration pulse applied at the gate electrode. With its unique characteristic features like good electrical property, chemical stability, biocompatibility, thermal stability and low power consumption HEMT sensors also have been used in several other applications like ion-sensing, pH sensing, gas sensing, etc. Therefore, the detection method becomes simple, fast, convenient and cost effective.