MicroRNA miR-497 is closely associated with poor prognosis in patients with cerebral ischemic stroke. Issue 1 (1st January 2021)

• Record Type: Journal Article
• Authors: Zhong, Changyang; Yin, Congguo; Niu, Guozhong; Ning, Li; Pan, Jinbo
• Is Part Of: Bioengineered. Volume 12:Issue 1(2021)
• Page Start: 2851
• Page End: 2862
• Publication Date: 2021-01-01
• Subjects: Ischemic stroke -- miR-497 -- oxidative stress response -- neuronal apoptosis; Biomedical engineering -- Periodicals; Biotechnology -- Periodicals; Microbiology -- Periodicals; 660.6
• DOI: 10.1080/21655979.2021.1940073
• Languages: English
• ISSNs: 2165-5987

Abstract

ABSTRACT: Cerebral ischemic stroke (CIS) is the most common type of stroke, which is highly hazardous. This investigation aims to analyze the correlation of miR-497 with CIS, so as to provide reliable evidence for clinical response to CIS and lay a solid foundation for follow-up research. Eighty-nine CIS patients and 39 concurrent physical examinees selected between June 2017 and October 2018 were enrolled as the research participants. Additionally, SD rats with increased miR-497 expression and normal SD rats were purchased for CIS modeling to observe the clinical implications of miR-497 in CIS, as well as the water content of brain tissue and neuronal apoptosis of rats. miR-497 expression was lower in CIS patients than in physical examinees, and that in patients with complete stroke (CS) was the lowest, which increased after treatment. As determined by the receiver operating characteristic curve (ROC) analysis, miR-497 had an outstanding diagnostic efficacy for CIS and was negatively correlated with the National Institutes of Health Stroke Scale (NIHSS) and MDA concentration, while positively related to SOD concentration. Prognostic follow-up demonstrated that decreased miR-497 expression in patients after treatment predicted an increased risk of prognostic death and recurrence. However, observed in rats, the water content of the brain tissue of rats with increased miR-497 expression was reduced, and the neuronal apoptosis rate of the brain tissue was inhibited. Taken together, with low expression in CIS, miR-497 is strongly related to CIS progression and is a candidate CIS marker. Graphical abstract: uf0001