Lobularity rather than hyperechoic foci/stranding on endoscopic ultrasonography is associated with more severe histological features in chronic pancreatitis. Issue 1 (9th November 2022)

• Record Type: Journal Article
• Authors: Inomata, Noriko; Masuda, Atsuhiro; Yamakawa, Kohei; Takenaka, Mamoru; Tsujimae, Masahiro; Toyama, Hirochika; Sofue, Keitaro; Sakai, Arata; Kobayashi, Takashi; Tanaka, Takeshi; Yamada, Yasutaka; Ashina, Shigeto; Gonda, Masanori; Abe, Shohei; Masuda, Shigeto; Uemura, Hisahiro; Kohashi, Shinya; Nagao, Kae; Harada, Yoshiyuki; Miki, Mika; Nakano, Ryota; Shiomi, Hideyuki; Kanzawa, Maki; Itoh, Tomoo; Fukumoto, Takumi; Kodama, Yuzo
• Is Part Of: Journal of gastroenterology and hepatology. Volume 38:Issue 1(2023)
• Page Start: 103
• Page End: 111
• Publication Date: 2022-11-09
• Subjects: chronic pancreatitis -- endoscopic ultrasonography -- histology -- hyperechoic foci/stranding -- lobularity; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.16047
• Languages: English
• ISSNs: 0815-9319

Abstract

Abstract: Background and Aim: Endoscopic ultrasonography (EUS) findings of the pancreatic parenchyma, such as hyperechoic foci/stranding and lobularity, may be associated with the severity of chronic pancreatitis (CP). However, the correlation between parenchymal EUS findings and histology remains unclear. We designed a large‐scale retrospective study analyzing over 200 surgical specimens to elucidate the association between parenchymal EUS findings and histological features. Methods: Clinical data of 221 patients with pancreatobiliary tumors who underwent preoperative EUS and pancreatic surgery between January 2010 and November 2020 were reviewed to investigate the association between parenchymal EUS findings and histological features at the pancreatic body. None of these patients met the definition of CP. Results: Of the 221 patients, 87 (39.4%), 89 (40.2%), and 45 (20.4%) had normal EUS findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity, respectively. In the multivariate analyses, parenchymal EUS findings significantly correlated with histological CP findings of fibrosis, inflammation, and atrophy (hyperechoic foci/stranding without lobularity vs hyperechoic foci/stranding with lobularity, odds ratio [95% confidence interval]: 4.1 [2.2–7.9] vs 31.3 [9.3–105.6], P trend < 0.001; 3.9 [1.9–8.2] vs 21.8 [8.0–59.4], P trend < 0.001; and 4.0 [2.0–7.8] vs 22.9 [7.0–74.5], P trend < 0.001, respectively). Further, a trend toward higher histological grade was observed in the following order: normal findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity. Conclusions: Endoscopic ultrasonography findings of the pancreatic parenchyma may be associated with the histological conditions in CP, such as pancreatic fibrosis, inflammation, and atrophy. Lobularity reflects more severe histological conditions than does hyperechoic foci/stranding.