Prognostic Role of Basophils to Predict Major Adverse Cardiac Cerebrovascular Events in ST Elevation Myocardial Infarction Patients: Egyptian PCI-Capable Center Experience. Issue 4 (28th December 2021)

• Record Type: Journal Article
• Authors: Ahmed, Walid Mohamed Kamel; Samy, Ebrahim; Radwan, Wahid Ahmed; Moharram, Ayman Nehad
• Is Part Of: Egyptian journal of critical care medicine. Volume 8:Issue 4(2021)
• Page Start: 83
• Page End: 89
• Publication Date: 2021-12-28
• Subjects: basophils, major adverse cardiac and cerebrovascular complications, ST elevation myocardial infarction; Intensive care nursing -- Periodicals; 616.02805
• DOI: 10.1097/EJ9.0000000000000033
• Languages: English
• ISSNs: 2090-7303

Abstract

Abstract: Background: Previous studies have shown that inflammation and immune cells play a critical role in acute ST elevation myocardial infarction (STEMI). Little is known about association of basophils and major adverse cardiac cerebrovascular events (MACCE) in STEMI. Aim of the study: To evaluate the association between basophil counts and in-hospital MACCE in STEMI patients. Methods: A retrospective analysis was conducted on 607 STEMI patients. Routine laboratory tests including complete blood picture on admission and 24 hours later. In-hospital MACCE were recorded. Results: The mean age was 57.7 ± 11.3 (488 male patients). Length of hospital stay was 6.5 ± 5.0 days. Patients who developed MACCEs were 79 (13%) with mortality (11%) Patients who experienced MACCE, had higher absolute basophil count on admission (1052.3 ± 1237.4 versus 466.0 ± 587.3, P < 70%), total leucocytic count within 1st 24 hours, basophilic counts on admission and within 1st 24 hours, contrast-induced nephropathy and need for organ support measures were potential significant predictors for MACCE. Absolute basophilic count on admission cutoff (370.0/mm 3 ) showed area under curve 0.71, sensitivity of 68.4% and specificity of 63.6% for predicting MACCE. Absolute basophilic count within 1st 24 hours cutoff (350.0/mm 3 ) showed area under curve 0.763, sensitivity of 73.4% and specificity of 68.7% for predicting MACCE. Conclusion: Basophilic counts on admission and 24 hours later were higher in MACCE group and could provide acceptable cutoffs for predicting in-hospital MACCE. Trial registration: Study ID ISRCTN17329623.