Catalytic enantioselective desymmetrization of meso-aziridines. Issue 3 (12th December 2022)

• Record Type: Journal Article
• Authors: Yang, Pei-Jun; Chai, Zhuo
• Is Part Of: Organic & biomolecular chemistry. Volume 21:Issue 3(2023)
• Page Start: 465
• Page End: 478
• Publication Date: 2022-12-12
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01935c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Over the past three decades, the catalytic enantioselective desymmetrization of meso -aziridines has evovled to be a ready synthetic toolkit for efficient construction of diverse useful nitrogen-containing molecules bearing contiguous stereocenters. Abstract : As a type of readily available small strained-ring heterocycle, meso -aziridines may undergo catalytic desymmetrizing transformations to empower the rapid construction of diverse nitrogen-containing structures bearing contiguous stereocenters, which have great relevance in natural product synthesis, drug development and the design and synthesis of chiral catalysts/ligands for asymmetric catalysis. This review outlines the advances achieved in the catalytic asymmetric desymmetrization of meso aziridines and highlights some promising avenues for further work in this realm.