Design of supramolecular hybrid nanomaterials comprising peptide-based supramolecular nanofibers and in situ generated DNA nanoflowers through rolling circle amplification. Issue 3 (29th November 2022)

• Record Type: Journal Article
• Authors: Sugiura, Shintaro; Shintani, Yuki; Mori, Daisuke; Higashi, Sayuri L.; Shibata, Aya; Kitamura, Yoshiaki; Kawano, Shin-ichiro; Hirosawa, Koichiro M.; Suzuki, Kenichi G. N.; Ikeda, Masato
• Is Part Of: Nanoscale. Volume 15:Issue 3(2023)
• Page Start: 1024
• Page End: 1031
• Publication Date: 2022-11-29
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d2nr04556g
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Design and development of multicomponent supramolecular hybrid materials by combining peptide nanofibers with DNA nanoflowers constructed by RCA is presented. Abstract : The artificial construction of multicomponent supramolecular materials comprising plural supramolecular architectures that are assembled orthogonally from their constituent molecules has attracted growing attention. Here, we describe the design and development of multicomponent supramolecular materials by combining peptide-based self-assembled fibrous nanostructures with globular DNA nanoflowers constructed by the rolling circle amplification reaction. The orthogonally constructed architectures were dissected by fluorescence imaging using the selective fluorescence staining procedures adapted to this study. The present, unique hybrid materials developed by taking advantage of each supramolecular architecture based on their peptide and DNA functions may offer distinct opportunities to explore their bioapplications as a soft matrix.