New dihydrobenzofuranoid from the marine-derived fungus Aspergillus ustus KMM 4664. Issue 19 (2nd October 2021)

• Record Type: Journal Article
• Authors: Oleinikova, Galina K.; Zhuravleva, Olesya I.; Berdyshev, Dmitrii V.; Menzorova, Natalia I.; Popov, Roman S.; Denisenko, Vladimir A.; Kirichuk, Natalya N.; Afiyatullov, Shamil Sh.
• Is Part Of: Natural product research. Volume 35:Issue 19(2021)
• Page Start: 3332
• Page End: 3335
• Publication Date: 2021-10-02
• Subjects: Aspergillus ustus -- marine-derived fungus -- dihydrobenzofuranoid -- secondary metabolites -- drimanes; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1689496
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new dihydrobenzofuran derivative (1 ), known depsipeptide emericellamide A (2 ), three known drimanes (3–5 ) and two artifact drimane derivatives (6, 7 ) were isolated from the marine-derived fungus Aspergillus ustus KMM 4664. Their structures were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configuration of 1 was determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 7 showed significant ability of the inhibition of spermatozoa to fertilize egg-cells of the sea urchin Strongylocentrotus intermedius with IC50 value 21 µM. Abstract : UF0001