New cyclopeptide alkaloids from the whole plant of Justicia procumbens L. Issue 21 (2nd November 2021)

• Record Type: Journal Article
• Authors: Lv, Jin-Peng; Yang, Shu; Dong, Jun-Xing; Jin, Hong
• Is Part Of: Natural product research. Volume 35:Issue 21(2021)
• Page Start: 4032
• Page End: 4040
• Publication Date: 2021-11-02
• Subjects: Justicia procumbens L -- Acanthaceae -- Cyclopeptide alkaloids -- justicianenes -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1758090
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three novel 14-membered cyclopeptide alkaloids, justicianenes B-D (1 -3 ), were isolated from the EtOH extract of the whole plant of Justicia procumbens L., and their structures were determined on the basis of detailed NMR spectroscopic data and the absolute stereochemistry of the ring-bonded α-amino acids in the cyclopeptide alkaloids were determined by ECD spectra. The isolated compounds were evaluated for their in vitro cytotoxicity against human cancer cell lines, including brest cancer MCF-7, cervix carcinoma HeLa, lung cancer A549 and H460, and diphyllin (14 ) showed moderate cytotoxicity against the HeLa, A549 and H460 cells with IC50 of 9.13, 23.12, 42.34 µM, respectively, justicianene D showed weak cytotoxicity against the MCF-7 cell with inhibition rate of 50% at the concentration of 90 µM. Graphical Abstract: