Activin A backs-up TGF-ß to promote regulatory T cells. (1st January 2021)

• Record Type: Journal Article
• Authors: De Martino, Mara; Daviaud, Camille; Vanpouille-Box, Claire
• Is Part Of: Oncoimmunology. Volume 10:Number 1(2021)
• Publication Date: 2021-01-01
• Subjects: Activin A -- immunosuppression -- TGF-beta -- radiotherapy -- regulatory T cells; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2021.1883288
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by radiotherapy and TGF-β blockade. Dual blockade of activin A and TGF-β may be necessary to reduce regulatory T cells mediated immunosuppression driven by radiation therapy.