Antifungal activity and theoretical study of synthesized pyrazole-imidazole hybrids. Issue 1 (February 2020)

• Record Type: Journal Article
• Authors: Zinad, Dhafer S.; Mahal, Ahmed; Shareef, Omar A.
• Is Part Of: IOP conference series. Volume 770:Issue 1(2020)
• Publication Date: 2020-02
• Subjects: Materials science -- Periodicals; 620.1105
• DOI: 10.1088/1757-899X/770/1/012053
• Languages: English
• ISSNs: 1757-8981

Abstract

Abstract: The density functional theory (DFT) and thermodynamic analyses were applied to study the stability and chemical reactivity of the synthesized CMPIP {2-chloro-4-(4-(1-methyl-1H-pyrazole-4-yl)-1H-imidazole-5-yl) pyridine} and MPIMPPA {4-(4-(1-methyl-1H-pyrazole-4-yl)- 1H-imidazole-5-yl)-N-(4-morpholino phenyl) pyridin-2-amine}. The results concluded that the CMPIP compound is more stable than MPIMPPA. The antifungal study was confirmed that the MPIMPPA has a higher inhibition zone against Aspergillus niger (A. niger), as compared to the standard drug used, while the CMPIP compound showed weaker activity than the positive control.