Hydroxybutyl chitosan/diatom-biosilica composite sponge for hemorrhage control. (15th May 2020)

• Record Type: Journal Article
• Authors: Zhang, Kaichao; Li, Jing; Wang, Yanan; Mu, Yuzhi; Sun, Xiaojie; Su, Chang; Dong, Yao; Pang, Jianhui; Huang, Liang; Chen, Xiguang; Feng, Chao
• Is Part Of: Carbohydrate polymers. Volume 236(2020)
• Publication Date: 2020-05-15
• Subjects: Diatom-biosilica -- Hydroxybutyl chitosan -- Hemostasis sponge; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.116051
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects. In this study, a composite sponge (H-D) based on hydroxybutyl chitosan (HBC) and diatom-biosilica (DB) was designed for hemorrhage control. H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11–16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control). In vitro coagulation tests demonstrated that H-D could provide strong interface effect to induce erythrocyte absorption and aggregation, as well as activating the intrinsic coagulation pathway and thus accelerated blood coagulation. These results proved that H-D composite sponge has great potential for hemorrhage control.