The role of CaMKII autophosphorylation for NMDA receptor-dependent synaptic potentiation. (1st August 2021)

• Record Type: Journal Article
• Authors: Giese, Karl Peter
• Is Part Of: Neuropharmacology. Volume 193(2021)
• Publication Date: 2021-08-01
• Subjects: Synaptic plasticity -- LTP -- Hippocampus -- Memory -- Signaling; Neuropsychopharmacology -- Periodicals; Autonomic Agents -- Periodicals; Neuropsychopharmacologie -- Périodiques; Neuropsychopharmacology; Periodicals; Electronic journals; 615.78
• DOI: 10.1016/j.neuropharm.2021.108616
• Languages: English
• ISSNs: 0028-3908

Abstract

Abstract: Potentiation of glutamatergic synaptic transmission is thought to underlie memory. The induction of this synaptic potentiation relies on activation of NMDA receptors which allows for calcium influx into the post-synapse. A key mechanistic question for the understanding of synaptic potentiation is what signaling is activated by the calcium influx. Here, I review evidences that at mature synapses the elevated calcium levels activate primarily calcium/calmodulin-dependent kinase II (CaMKII) and cause its autophophorylation. CaMKII autophosphorylation leads to calcium-independent activity of the kinase, so that kinase signaling can outlast NMDA receptor-dependent calcium influx. Prolonged CaMKII signaling induces downstream signaling for AMPA receptor trafficking into the post-synaptic density and causes structural enlargement of the synapse. Interestingly, however, CaMKII autophosphorylation does not have such an essential role in NMDA receptor-dependent synaptic potentiation in early postnatal development and in adult dentate gyrus, where neurogenesis occurs. Additionally, in old age memory-relevant NMDA receptor-dependent synaptic plasticity appears to be due to generation of multi-innervated dendritic spines, which does not require CaMKII autophosphorylation. In conclusion, CaMKII autophosphorylation has a conditional role in the induction of NMDA receptor-dependent synaptic potentiation. This article is part of the Neuropharmacology Special Issue on 'Glutamate Receptors – NMDA receptors'. Highlights: CaMKII autophosphorylation induces NMDA receptor-dependent LTP at mature synapses. CaMKII autophosphorylation is critical for functional and structural changes. At immature synapses LTP induction does not require CaMKII autophosphorylation. At old age memory formation does not involve CaMKII autophosphorylation.