Preparation and application of calcium phosphate nanocarriers in drug delivery. (15th December 2022)

• Record Type: Journal Article
• Authors: Qiu, Chong; Wu, Yanyan; Guo, Qiuyan; Shi, Qiaoli; Zhang, Junzhe; Meng, Yuqing; Xia, Fei; Wang, Jigang
• Is Part Of: Materials today bio. Volume 17(2023)
• Publication Date: 2022-12-15
• Subjects: Calcium phosphate -- Nanocarrier -- Drug delivery -- Preparation -- Application; Materials science -- Periodicals; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 620.1
• DOI: 10.1016/j.mtbio.2022.100501
• Languages: English
• ISSNs: 2590-0064

Abstract

Abstract: Calcium phosphate nanoparticles represent promising materials for drug delivery because of its favorable properties, including biocompatibility, biodegradability and strong affinity for binding to nucleic acids (pDNA, siRNA, miRNA, etc.) and therapeutic drugs (cisplatin, carboplatin, paclitaxel, gefitinib, doxorubicin, etc.). Various strategies to prepare the size-controllable, stable, targeting and pH-responsive CaP nanocarriers have been extensively developed as the potential candidates in clinic. This review discusses the mostly recent developments in the design of calcium phosphate nanocarriers as drug delivery systems and therapeutic agents. Additionally, the advantage is unquestionably demonstrated and the obstacles are thoroughly examined in order to overcome future clinical issues. Graphical abstract: Image 1