Cyclodextrin metal-organic framework as vaccine adjuvants enhances immune responses. (1st January 2021)

• Record Type: Journal Article
• Authors: Li, Congcong; Chen, Chaoxi; Wei, Yucai; Tan, Min; Zhai, Shuo; Zhao, Juebo; Wang, Lu; Dai, Tao
• Is Part Of: Drug delivery. Volume 28:Number 1(2021)
• Page Start: 2594
• Page End: 2602
• Publication Date: 2021-01-01
• Subjects: γ-cyclodextrin metal-organic framework -- vaccine adjuvants -- immune responses; Drug delivery systems -- Periodicals; Drug targeting -- Periodicals; 615.05
• DOI: 10.1080/10717544.2021.2012306
• Languages: English
• ISSNs: 1071-7544

Abstract

Abstract: It is urgently needed to develop novel adjuvants for improving the safety and efficacy of vaccines. Metal-organic frameworks (MOFs), with high surface area, play an important role in drug delivery. With perfect biocompatibility and green preparation process, the γ-cyclodextrin metal-organic framework (γ-CD-MOF) fabricated with cyclodextrin and potassium suitable for antigen delivery. In this study, we modified γ-CD-MOF with span-85 to fabricate the SP-γ-CD-MOF as animal vaccine adjuvants. The ovalbumin (OVA) as the model antigen was encapsulated into particles to investigate the immune response. SP-γ-CD-MOF displayed excellent biocompatibility in vitro and in vivo . After immunization, SP-γ-CD-MOF loaded with OVA could induce high antigen-specific IgG titers and cytokine secretion. Meanwhile, SP-γ-CD-MOF also significantly improved the proliferation of spleen cells and activated and matured the bone marrow dendritic cells (BMDCs). The study showed the potential of SP-γ-CD-MOF in vaccine adjuvants and provided a novel idea for the development of vaccine adjuvants.