An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019. (14th May 2020)

• Record Type: Journal Article
• Authors: Bordoni, Veronica; Sacchi, Alessandra; Cimini, Eleonora; Notari, Stefania; Grassi, Germana; Tartaglia, Eleonora; Casetti, Rita; Giancola, Maria Letizia; Bevilacqua, Nazario; Maeurer, Markus; Zumla, Alimuddin; Locatelli, Franco; De Benedetti, Fabrizio; Palmieri, Fabrizio; Marchioni, Luisa; Capobianchi, Maria R; D'Offizi, Gianpiero; Petrosillo, Nicola; Antinori, Andrea; Nicastri, Emanuele; Ippolito, Giuseppe; Agrati, Chiara
• Is Part Of: Clinical infectious diseases. Volume 71:Number 16(2020)
• Page Start: 2272
• Page End: 2275
• Publication Date: 2020-05-14
• Subjects: COVID-19 -- inflammation -- NK cells -- cytotoxic cells -- MDSC; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa577
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3 + T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.