Family health conditions and parental occupational status modify the relationship between pediatric-onset multiple sclerosis and parental health-related quality of life. (March 2023)

• Record Type: Journal Article
• Authors: O'Mahony, Julia; Banwell, Brenda; Laporte, Audrey; Brown, Adalsteinn; Bolongaita, Lady; Bar-Or, Amit; Yeh, E Ann; Marrie, Ruth Ann
• Is Part Of: Multiple sclerosis. Volume 29:Number 3(2023)
• Page Start: 447
• Page End: 456
• Publication Date: 2023-03
• Subjects: Pediatric -- multiple sclerosis -- demyelination -- health-related quality of life -- quality of life -- caregiver -- parent; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/13524585221144413
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: The health-related quality of life (HRQoL) of children with multiple sclerosis (MS) is mediated by the HRQoL of their parents. Understanding factors that modify the relationship between the child's MS diagnosis and parental HRQoL would inform interventions to improve the HRQoL of both parents and children living with MS. Objective: We evaluated whether the association between an MS diagnosis during childhood and parental HRQoL is modified by the presence of a family health condition or low socioeconomic position (SEP). Methods: Parents of children with MS or the transient illness, monophasic-acquired demyelinating syndromes (monoADS), were enrolled in a prospective Canadian study. Multivariable models evaluated whether the association between a child's MS diagnosis (vs. monoADS) and parental HRQoL was modified by ⩾1 family health conditions or low SEP. Results: Two hundred seven parents and their children with MS ( n = 65) or monoADS ( n = 142) were included. We found a synergistic effect of an MS diagnosis and a family health condition on parental HRQoL. We also found a synergistic effect of having MS and a low SEP on parental HRQoL. Conclusion: Parents of children with MS who have another family health condition or a low SEP are at particularly high risk for low HRQoL.