Evaluating the central vein sign in paediatric-onset multiple sclerosis: A case series study. (March 2023)

• Record Type: Journal Article
• Authors: Boccia, Vincenzo Daniele; Lapucci, Caterina; Cellerino, Maria; Tazza, Francesco; Rossi, Andrea; Schiavi, Simona; Mancardi, Maria Margherita; Inglese, Matilde
• Is Part Of: Multiple sclerosis. Volume 29:Number 3(2023)
• Page Start: 475
• Page End: 478
• Publication Date: 2023-03
• Subjects: Paediatric-onset multiple sclerosis -- central vein sign -- relapsing remitting multiple sclerosis -- MRI -- gradient echo plural contrast imaging -- SWI; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/13524585221142319
• Languages: English
• ISSNs: 1352-4585

Abstract

The central vein sign (CVS) has been proposed as a biomarker of multiple sclerosis (MS). In adult-onset MS (AOMS), 40%-threshold of CVS positive (+) lesions demonstrated high accuracy for MS diagnosis. However, CVS+ lesions' performance has not been characterized in paediatric-onset (POMS) yet. We compared the CVS contribution to MS diagnosis in 10 POMS and 12 disease-duration-matched AOMS patients. Three POMS patients did not meet the 40%-threshold, while all AOMS patients were correctly diagnosed as having MS. The high proportion of periventricular confluent lesions, excluded from the CVS assessment, seemed to impair CVS sensitivity in POMS diagnosis.