Low socioeconomic status was associated with a higher mortality risk in multiple sclerosis. (March 2023)

• Record Type: Journal Article
• Authors: Calocer, Floriane; Ng, Huah Shin; Zhu, Feng; Zhao, Yinshan; Dejardin, Olivier; Leray, Emmanuelle; Defer, Gilles; Evans, Charity; Fisk, John D; Marrie, Ruth Ann; Tremlett, Helen
• Is Part Of: Multiple sclerosis. Volume 29:Number 3(2023)
• Page Start: 466
• Page End: 470
• Publication Date: 2023-03
• Subjects: Multiple sclerosis -- socioeconomic disparities -- socioeconomic status -- mortality risk -- population-based study; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/13524585221129963
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: The relationship between socioeconomic status (SES) and mortality among persons with multiple sclerosis (PwMS) is poorly understood. Objective: To investigate the association between SES and mortality risk in PwMS. Methods: From health-administrative data, we identified 12, 126 incident MS cases with a first demyelinating event (MS 'onset') occurring between 1994 and 2017. Cox proportional hazard model assessed the association between socioeconomic status quintiles (SES-Qs) at MS onset and all-cause mortality. Results: Lower SES-Qs were associated with higher mortality risk; adjusted hazard ratios: SES-Q1 (most deprived) =1.61 (95% confidence interval (CI) = 1.36–1.91); SES-Q2 = 1.26 (95% CI = 1.05–1.50); SES-Q3 = 1.22 (95% CI = 1.02–1.46); SES-Q4 = 1.13 (95% CI = 0.94–1.35) versus SES-Q5 (least deprived). Conclusion: A lower SES was associated with higher mortality risk in PwMS.