Differential vulnerability of thalamic nuclei in multiple sclerosis. (February 2023)

• Record Type: Journal Article
• Authors: Blyau, Simon; Koubiyr, Ismail; Saranathan, Manojkumar; Coupé, Pierrick; Deloire, Mathilde; Charré-Morin, Julie; Saubusse, Aurore; Zhang, Bei; Rutt, Brian; Dousset, Vincent; Brochet, Bruno; Ruet, Aurélie; Tourdias, Thomas
• Is Part Of: Multiple sclerosis. Volume 29:Number 2(2023)
• Page Start: 295
• Page End: 300
• Publication Date: 2023-02
• Subjects: MRI -- thalamus -- thalamic nuclei -- segmentation -- volumetry -- differential vulnerability; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/13524585221114247
• Languages: English
• ISSNs: 1352-4585

Abstract

Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.